Structural, Chemical, and Clinical Frontiers in the Development of Oral Semaglutide: A Strategic Perspective on Peptidomimetic Engineering

Ratnesh Jain (ICT Mumbai; Mumbai Biocluster)

Mumbai Biocluster White Paper MBC_WHITEPAPER_001 · 1 Feb 2026 · PDF · 2.5 MB

Summary

How GLP-1 receptor agonists moved from injectables to oral formulations, covering semaglutide's structural modifications, such as Aib substitution and fatty-diacid acylation, and the engineering challenges of oral delivery.